Tyrosinase plays a crucial role in melanin production as it controls the rate of melanin deposition. 4-Butylresorcinol has an inhibitory effect on melanin production by directly suppressing the activity of tyrosinase and inhibiting the synthesis of tyrosinase in B16 melanoma cells, without causing any cytotoxicity. In some in vitro studies have shown that 4-butylresorcinol can inhibit the production of melanin, as well as the activity of tyrosinase and TRP-1.

Mechanism of action

Before melanin synthesis, interfere with the synthesis and glycosylation of tyrosinase to prevent the enzyme from being absorbed by melanocytes

During melanin synthesis, inhibition of enzyme activity acts as a competitive inhibitor of tyrosinase and TRP1 enzymes, reducing the formation of byproducts that promote melanin production.

After the synthesis of melanin, it enhances tyrosinase degradation, inhibits the transfer of melanocytes to keratinocytes, and has a light stripping effect due to the action of fatty acids. This function is strengthened by the presence of fatty acids and regulates tyrosinase degradation.

Functional characteristics

Whitening Effect: Improves uneven skin tone and reduces skin discoloration caused by UV radiation

Excellent antioxidants

Good stability and safety, no potential irritation or sensitivity