Overview

Astragalus is the dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao) or Astragalus membranaceus (Fisch.) Bge. of the legume family. Astragalus is a perennial herb, cold-resistant, drought-resistant, fear of heat, fear of waterlogging, mostly grown in dry sunny hillside meadows or sunny forest edge scrub. Cultivation should be cold and dry climate, with good drainage, deep sandy soil is good. Mongolian Astragalus is distributed in China's northeastern and northern provinces and regions; membrane pods of Astragalus is distributed in China's northern, northwestern, northeastern and southwestern provinces and regions. Astragalus is a commonly used Chinese medicine, warm, sweet, with tonifying qi and solid surface, diuretic toxin, drainage of pus, astringent sores and muscle function, used for qi deficiency weakness, loose food, Qi subsidence, prolonged leakage and prolapse of the anus, blood in the stool and leakage, surface of the false sweating, qi deficiency oedema, long-time ulcers do not converge, chronic nephritis, proteinuria, diabetes and other diseases. Modern pharmacological studies have shown that Astragalus has the effect of enhancing the body's immune function, strengthening the heart and lowering blood pressure, lowering blood sugar, diuretic, anti-aging, anti-fatigue and so on. Astragalus in the main active ingredients for astragalus polysaccharides (astragaluspolysaccharides), astragalus saponins (astragalusussaponins) and astragalus isoflavones (isoflavones), astragalus saponins in the astragalus methyl glycoside (astragalusoside Ⅳ) as an evaluation of the quality of astragalus medicinal herbs. At present, astragalus saponin (astragaloside IV) is mainly used as the standard to evaluate the quality of Astragalus.

Astragaloside A 5%  Brown Powder

Use of Astragaloside A

Astragaloside A is an isomer of Astragaloside IV. Astragaloside A is an isomer of astragaloside IV. Astragaloside has protective effects on cardiovascular, immune, digestive and nervous systems.

Pharmacological effects

1. Astragaloside inhibits oxidative stress, reduces cellular reactive oxygen species (ROS) levels, enhances the antioxidant defense system, increases anti-apoptotic and anti-inflammatory pathways, as well as regulates T-cell differentiation and infiltration in the central nervous system. This suggests that astragaloside may be clinically useful for the treatment and prevention of MS.In conclusion, astragaloside may be useful in a wide range of diseases by modulating the immune action of the body.

2. Astragaloside has a protective effect on cerebral, pulmonary, renal and cardiac injuries caused by ischemia-reperfusion.

3. Astragaloside has a protective effect on myocardial injury caused by ischemia and hypoxia, in addition to its effect on myocardial hypertrophy, myocarditis, myocardial fibrosis and so on.

4. Astragaloside, through its anti-inflammatory activity, in turn, has a role in pneumonia, airway inflammation and asthma, acute pancreatitis.

5. Astragaloside plays an anti-CVB3 virus role by up-regulating the expression of IFN-γ at the mRNA level.

6. Astragaloside has a hypoglycemic effect by inhibiting the activities of hepatic glycogen phosphorylase (GP) and glucose-6-phosphatase (G6Pase), inducing the secretion of TNF-alpha in 3T3-L1 adipocytes, and improving the tolerance of insulin.

7. Astragaloside has a certain inhibitory effect on lung cancer, liver cancer, breast cancer and stomach cancer in vitro.

Toxicity

The effects of Astragaloside on embryonic and fetal development of SD rats and New Zealand rabbits were studied. The results showed that astragaloside showed maternal toxicity at a dose greater than 1 mg kg-1 and fetal toxicity at a dose greater than 0.5 mg kg-1 . Therefore, pregnant women are advised to use Astragaloside with caution. Further studies have shown that astragaloside significantly delayed hair development, eye opening time, and Parry's reflex in rats. However, Astragaloside had no significant effect on memory and learning ability.