2,3,6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno(9,10)cyclodeca(1,2-b)furan-9(1aH)-one;Parthenolide;4Xi-germacra-1(10),11(13)-dien-12-oic acid, 4,5-epoxy-6.alpha.-hydroxy-, gamma-lactone;Oxireno(9,10)cyclodeca(1,2-B)furan-9(1ah)-one, 2,3,6,7,7A,8,10A,10B-octahydro-1A,5-dimethyl-8-methylene-;Parthenlide;4,5ξ-epoxy-6α-hydroxy-4ξH-germacra-1(10)t,11(13)-dien-12-oic acid-lactone.

Uses 

For content determination/identification/pharmacological experiments.

Pharmacological effects:Mainly used in the treatment of skin infections, rheumatism and migraine, and can cause cell cycle blockage in tumor cells, inhibit the proliferation of tumor cells.

Parthenolide in contact with your skin may result in dermatitis. Brief or occasional

contact may not pose a problem.

Where is parthenolide found?

Parthenolide is a sesquiterpene lactone which occurs naturally in high concentrations

in the Compositae feverfew (Tanacetum parthenium), after which it is named.

Feverfew is well known in natural medicine and cosmetics.

Parthenolide is also fund in other genera of Compositae and in Magnoliaceae from all

over the world, and it may be a powerful screening agent for plants belonging to these

genera and extracts from those plants used with e.g. cosmetics and topical medicines.

How to avoid parthenolide  Avoid contact with cosmetics and topical medicines which contain extracts from plants  belonging to the Compositae/Asteraceae family, especially feverfew.

(Hobby) gardeners should protect their skin by using protective gloves when working

with Compositae and Magnoliacea. Plant particles may cause airborne allergic contact

dermatitis.

If you suspect that you are being exposed to this allergen at work, consult your

employer.