Tranexamic acid, its chemical name is trans-4-aminomethylcyclohexanecarboxylic acid, white crystalline powder; odorless and slightly bitter. Soluble in water, almost insoluble in ethanol, acetone, chloroform or ether. The molecular formula is C8H15NO2, the molecular weight is 157.21000, the density is 1.095 g / cm3, the melting point is 233ºC, and the boiling point is 300.2ºC at 760 mmHg.

It is a medication used to treat or prevent excessive blood loss from major trauma, post partum bleeding, surgery, tooth removal, nose bleeds, and heavy menstruation. It is also used for hereditary angioedema. It is taken either by mouth or injection into a vein.

Quality Index of Tranexamic acid

Functions & application of Tranexamic Acid      

Medical uses

It is used to prevent and treat blood loss in a variety of situations, such as dental procedures for haemophiliacs, heavy menstrual bleeding, and surgeries with a high risk of blood loss.

Trauma

It has been found to decrease the risk of death in people who have significant bleeding due to trauma. Its main benefit is if taken within the first three hours.

Vaginal bleeding

Tranexamic acid is used to treat heavy menstrual bleeding. When taken by mouth it both safely and effectively treats regularly occurring heavy menstrual bleeding. Another study demonstrated that the dose does not need to be adjusted in females who are between ages 12 and 16. A 2017 trial found that it decreased the risk of death from bleeding from 1.9% to 1.5% in women with postpartum bleeding. The benefit was greater when the medication was given within three hours.

Surgery

It is used in orthopaedic surgery to reduce blood loss, to the extent of reducing or altogether abolishing the need for perioperative blood collection. It is of proven value in clearing the field of surgery and reducing blood loss when given before or after surgery. Drain and number of transfusions are reduced.

In surgical corrections of craniosynostosis in children, it reduces the need for blood transfusions.

In spine surgery, e.g. scoliosis correction with posterior spinal fusion using instrumentation, to prevent excessive blood loss.

In cardiac surgery, both with and without cardiopulmonary bypass e.g. coronary artery bypass surgery, it is used to prevent excessive blood loss. It replaces aprotinin.