Artemisinin, also called qinghaosu, antimalarial drug  isolated from the plant Artemisia annua, a herb described in Chinese traditional medicine. Artemisinin is a sesquiterpene lactone (a compound made up of three isoprene units bound to cyclic organic esters) and is distilled from the dried leaves or flower clusters of A. annua.
 

Functions of  99% Artemisinin  powder

When it comes to artemisinin, people will first think of its anti-malarial function. WHO believes that artemisinin is the best drug for the treatment of malaria resistance. The combination therapy based on artemisinin drugs is also the current treatment of malaria. The most effective and important means. However, with the deepening of research in recent years, other effects of artemisinin have also been increasingly discovered and applied research, such as anti-tumor, treatment of pulmonary hypertension, anti-diabetes, embryo toxicity, anti-fungal, immune regulation, etc.

1. Antimalarial

Malaria (commonly known as Pingzizi cold fever) is an insect-borne infectious disease. It is an infectious disease caused by the bite of the anopheles infected by the malaria parasite. It can cause liver and splenomegaly after multiple attacks for a long time, and is accompanied by anemia. symptom. Malaria can be treated to a certain extent, and artemisinin is indispensable. The peroxygen bond in artemisinin structure is oxidative and is an essential group for malaria resistance. The mechanism of action is that the free radical group produced by artemisinin in the body combines with the malaria protein, which changes the structure of the cell membrane of Plasmodium. After the free radical group binds to the malaria protein, the bilayer membrane of the mitochondria will rupture and eventually fall off, resulting in the destruction of the cell structure and function of the malaria parasite, and the chromatin in the nucleus will also be affected to some extent. On the other hand, amino acids are the basic substances that make up proteins, after the effect of artemisinin. Plasmodium's absorption of isoleucine is reduced, resulting in the inhibition of worm protein synthesis. Artemisia annua can not only kill pathogens, but also has anti-schistosome, anti-toxoplasma infection, anti-pneumocystis carinii and anti-coccidial effects. Clinical trials have shown that artemisinin and its derivatives have not found particularly obvious side effects during the treatment of malaria.

2. Treatment of pulmonary hypertension

Pulmonary hypertension (PAH) is a pathophysiological state characterized by pulmonary artery remodeling and characterized by a rise in pulmonary artery pressure to a certain limit, which can be a complication or syndrome. Artemisinin is used to treat pulmonary arterial hypertension: dilate blood vessels to reduce pulmonary artery pressure and improve symptoms in patients with PAH. Zaiman et al. found that artemisinin has anti-inflammatory effects. Artemisinin and its core substances have inhibitory effects on various inflammatory factors, and can also inhibit the production of nitric oxide by inflammatory mediators; artemisinin has immunomodulatory effects; Feng Yibai, etc. Through experimental research, it was found that artemisinin can inhibit the proliferation of vascular endothelial cells and vascular smooth muscle cells, and thus play an important role in the treatment of PAH; artemisinin can inhibit the activity of matrix metalloproteinases, thereby inhibiting pulmonary vascular remodeling; Artemisinin can inhibit the expression of PAH-related cytokines and further enhance the anti-vascular remodeling effect of artemisinin.

3. Immune regulation

The study found that the dosage of artemisinin and its derivatives can better inhibit T lymphocyte mitogen without inducing cytotoxicity, thereby inducing the proliferation of mouse splenic lymphocytes. This finding has a good reference value for the treatment of autoimmune diseases mediated by T lymphocytes. Artemisia annua L. vinegar has the effect of enhancing non-specific immunity and can increase the total complement activity of mouse serum. Dihydroartemisinin can directly inhibit the proliferation of B lymphocytes, thereby reducing the secretion of autoantibodies by B lymphocytes, reducing the humoral immune response, having a certain inhibitory effect on humoral immunity, and reducing immune complexes. Formation.

Applications of Artemisia Annua Extract  

1. Applied in food field, in summer it will be serve as cool drinks which is good for prevention and treatment of heat stroke;

2. Applied in health product field, artemisinin can be made into capsules or oral liquid to regulate the immune system;

3. Applied in pharmaceutical field, artemisinin has treatment effects on vivax malaria, plasmodium falciparum and chloroquine.