What’s Fisetin?

Fisetin, or called 3,3′,4′,7-tetrahydroxyflavonoid, is an active ingredient from a plant extract, such as Rhus Succedanea, Continus Coggygria, or Wax Tree Extract. it has been in the spotlight most recently for its senolytic potential.

Fisetin Sources

Fruits and vegetable sources

Fisetin is a natural polyphenolic flavonol which exists in many fruits and vegetables, such as strawberries(16mg),apples(3mg),persimmons(1mg),onions(0.4mg),grapes(0.3mg),kiwi(0.2mg),cucumbers(0.01mg), peaches(0.06mg) etc.

Plant sources

You can find fisetin in a wide variety of plants, naturally extracted from Rhus succedanea. L or wax tree(Toxicodendron succedaneum) or Smoketree (Cotinus coggygria scop.) except fruit and vegetables.

Fisetin bioavailability

Due to poor water solubility and high lipophilicity, fisetin has low oral bioavailability, which limits its further development and clinical application, therefore, high-availability forms of fisetin will bring great promise. Liposomal fisetin powder is popular among our clients in the United States and Europe.

Fisetin Benefits

Fisetin extends longevity

Fisetin’s ability to activate the AMPK pathway, combined with its other biochemical properties, enables this substance to have a senescent cell removal ability comparable to the current mainstream Senolytics drugs (a class of experimental drugs that can target and remove senescent cells).

—-From the Department of Respiratory and Critical care medicine, west China hospital team

Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.

  –From Matthew J Yousefzadeh

Fisetin anticancer

Fisetin, a polyphenol with pleiotropic pharmacological properties, has been used to inhibit various stages of cancer cells (proliferation, invasion), arrest cell cycle progression, inhibit cell growth, induce apoptosis, induce polymerase ( PARP) cleaves, and regulate the expression of Bcl-2 family proteins in different cancer cell lines (HT-29, U266, MDA-MB-231, BT549, and PC-3M-luc-6). In addition, fisetin inhibited the activation of PKCα/ROS/ERK1/2 and p38 MAPK signaling pathways, decreased NFNF-κB activation, and down-regulated the level of the oncoprotein securin. Fisetin also inhibits cell division, proliferation, and invasion, and reduces TET1 expression levels.

Fisetin inhibits cancer cell stages, arrests the progression of the cell cycle and cell growth, and induces apoptosis, showing promising anticancer activity in cancer.

 

Fisetin Improve brain Health

Anti-inflammatory and antioxidant effects of fisetin, as well as its effects on regulated cell death-oxygen/ferroptosis pathways, the gut microbiome, and its senescence activity, demonstrate that it modulates a large number of pathways associated with brain dysfunction The ability to effectively prevent Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, stroke (ischemic and hemorrhagic) and traumatic brain injury in preclinical models.

 

Fisetin applications

Because of its various pharmacological properties, the bioactive flavonol molecule Fisetin demands an increase in dietary supplements, it can combinate many ingredients.

Fisetin+quercetin

Fisetin and quercetin have a similar molecule structure, their potential for biological activity has been established, particularly in regulating a range of cancer signaling pathways. The combined formula promotes cellular health, longevity, healthy aging, improves cognition, and protects cells from stress-related damage.

Fisetin+ resveratrol+NMN Formula

Nicotinamide mononucleotide (NMN), NAD boosters, has beneficial effects on diseases and symptoms of aging. Fisetin seems to be the most potent natural senolytic (R). Resveratrol, the famous anti-aging substance, the combination of the three will become a powerful anti-aging artifact.

Fisetin+ glutathione Formula

Glutathione is the body’s “master antioxidant” and detoxifier for every cell in the body, while Fisetin acts as an antioxidant that increases GSH and helps maintain mitochondrial function in the presence of oxidative stress.

Fisetin+fenugreek

The brand Bio-Fisetin from Life-extension, combinate with galactomannans isolated from herb fenugreek, greatly improved its bioavailability.

Fisetin+Spermidine

the natural polyamine spermidine powder extracted from the wheat germ(Triticum aestivum L) has remarkable benefits to health and longevity. Fisetin+Spermidine supplement stack opens a new avenue in the protection and restoration of memory abilities at a higher age.

 

Fisetin Specifications

Bulk Fisetin powder and small samples are both available at IdoBio with various specifications:

• 50% Fisetin powder
• 98% Fisetin powder
• liposomal fisetin powder
• custom standardized fisetin powder

Fisetin-LP powder,fisetin-UM powder,fisetin-WS powder, these special specifications IdoBio Co., Ltd can customize upon your detailed request.

Fisetin side effects

Currently, there are no reports of adverse effects in humans. Some clinical trial data are limited for long-term users. If you have any adverse reactions after taking fisetin supplements, should stop taking and consult your doctor.

Fisetin dosage

Fisetin is very deficient in the human body, and in the daily diet, intake of about 0.4mg daily, if we want it to benefit us, the current recommended daily dose is 20-100mg.