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Basic Introduction of Myricetin Powder
Myricetin, also known as Cannabiscetin, Myricetol, is an effective ingredient extracted from the stems and leaves of rattan tea or bayberry bark and leaves. The pharmacological activity of scavenging free radicals, and the pharmacological effects of myricetin, a compound substituted by flavonoids to scavenging free radicals, as well as protecting the liver, reducing enzymes and reducing yellowing, and improving immune function. It is generally believed that other flavonoids (such as kaempferol or quercetin) are more involved in anti-osteoporosis and bone health.
Myricetin powder is a kind of polyhydroxyflavonol compound, it is yellow needle-like crystals. The ultraviolet spectrum has maximum absorption at 376.5nm (band I) and 254 (band II). The infrared spectrum shows cholesterol (3575, 3380, 3255cm- 1), conjugated carbonized group (1646cm-1), double bond and aromatic ring carbon skeleton vibration (1660, 1550, 1454cm-1) absorption.
This compound dissolves methanol, ethanol and toluene, slightly degrades toluene, does not dissolve water, petroleum ether (60-90℃), chloroform, toluene and n-hexane, and has poor resistance to photolysis. It is relatively stable under acidic conditions, but moderate It can be easily destroyed in sexual and alkaline environment.
Chemical Profile
IUPAC Name: 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
Molecular Formula: C₁₅H₁₀O₈
Natural Sources: Berries, walnuts, herbs (Myrica spp.), and red wine
Solubility: Poor water solubility (~16 μg/mL), enhanced by glycosylation
Mechanisms of Action
Kinase Modulation:
PI3K/Akt/mTOR pathway inhibitor
Selective CDK and JAK/STAT suppression
Redox Activity:
Direct ROS scavenging (ORAC 3.5× quercetin)
Nrf2/ARE pathway activation
Epigenetic Effects:
DNMT and HDAC inhibition
miRNA expression modulation
Therapeutic Applications
Oncology Adjuvant:
Chemosensitizer in multidrug-resistant cancers
Anti-angiogenic (VEGFR-2 inhibition)
Metabolic Regulation:
AMPK-mediated glucose uptake
PPARγ partial agonism
Neurological Protection:
Aβ fibril disruption
MAO-B inhibition (Ki = 0.22 μM)
Formulation Advances
Nano-Delivery Systems:
PLGA nanoparticles (↑ bioavailability 8-fold)
Phospholipid complexes (logP optimization)
Prodrug Development:
Myricetin-3-O-glucuronide (improved absorption)
Clinical Translation
Dosing Range: 50-300 mg/day (Phase I/II trials)
PK Profile:
Tmax ~4-6 hours (oral)
Extensive phase II metabolism
Safety Data:
NOAEL >1000 mg/kg (rodent)
CYP3A4 substrate (drug interaction potential)
Commercial Viability
Market Position:
Premium-priced flavonoid (>$2000/kg)
Growing demand for senotherapeutics
Regulatory Pathway:
DSHEA-compliant (US)
FOSHU consideration (Japan)
This pleiotropic flavonoid bridges nutraceutical and pharmaceutical applications, with particular promise in age-related chronic diseases. Current research focuses on overcoming its pharmacokinetic limitations through innovative delivery systems.
Function of Bayberry Extract Myricetin Powder
1. Similar to kaempferol, myricetin appears to reduce blood sugar levels by increasing muscle cell uptake and increasing liver glycogen synthesis.
2. Myricetin has been shown to inhibit the uptake of glucose into cultured rat fat cells.
3. In vitro studies have shown that myricetin can prevent oxidative damage of osteoblasts, and may prevent osteoporosis through this mechanism and other mechanisms (such as increased calcium deposition). Note that the concentration of this effect is 20uM.
4. When studying dietary correlation, higher myricetin intake seems to be associated with a lower risk of prostate cancer.
5. Protecting liver;
6. A good dyeing agent.
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