What is NMN?

NMN (Nicotinamide Mononucleotide) is a nucleotide derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of niacin. Humans also use NMN to produce nicotinamide adenine dinucleotide (NADH).

NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered to be a key component to increase the level of NAD+ in cells.

The beta form is an active anomer. NMN is naturally constructed by the reaction catalyzed by nicotinamide phosphoribosyltransferase, which is formed by the reaction between the phosphate group and the nucleoside containing nicotinamide (the amide form of vitamin B3) and ribose. Yes, NMN is a biologically active nucleotide with a pyridine base.

What are Benefits of NMN?

• NMN can inhibit age-related weight gain, enhance energy metabolism and physical activity, improve insulin sensitivity, improve eye function, improve mitochondrial metabolism and prevent age-related changes in gene expression.

• Promote blood vessel health and blood flow: We rely on skeletal muscle to maintain movement, stability and strength. In order to stay strong and in good shape, these muscles must consume a lot of key energy molecules, such as glucose and fatty acids.

• Animal studies have shown that: NMN can prevent many aging-related health declines, such as hardening of blood vessels and oxidative stress.

• Improve muscle endurance and strength: Animal studies have shown that mice fed with NMN for a long time have better energy metabolism and no obvious side effects. As we age and our own NAD+ supply decreases, the health of our muscles becomes more and more important.

• Prevention of heart disease: Not only can the human heart not rest, it cannot even slow down without causing serious problems. Therefore, the energy demand of the heart is huge. In order to keep it running, it needs to exert all the NAD+ as much as possible, that is, it needs a stable supply of NMN.

• Reduce the risk of obesity: In animal studies, NMN has shown an effect that mimics calorie restriction (CR), but it requires long-term use.

• Enhance the maintenance of DNA repair: NAD+ made of NMN will activate a group of proteins called Sirtuins. However, in order to function, sirtuins rely on NAD+. Recent studies have shown that feeding mice with NMN activates Sirtuins and leads to more stable telomeres.

• Increase mitochondrial function: Without mitochondria, we cannot survive. Mitochondrial abnormalities caused by NAD+ loss may even affect neurological diseases.