Arctiin(NSC 315527) is a plant lignan that can be extracted from burdock seeds and has anticancer activity.

arctiin (ARC) is a biennial herb from the genus ArctiumlappaL in the Asteraceae family. Lignan-like compounds extracted from the dried ripe fruit of Burdock are also present in small amounts in burdock leaves.

Burdock seed is a traditional Chinese medicine in our country, mainly used for the treatment of wind and heat cold, measles, carbuncle, swollen sore and other diseases, modern pharmacology has proved that burdock seed also has antibacterial, anti-tumor, lowering blood sugar and other multiple effects.

Drug value

Arctiin is one of the main active substances in arctiin, its content in arctiin is about 8.4%, and the content of arctiin should reach more than 5% of the quality of medicinal materials under the Chinese Pharmacopoeia (2005 edition) Arctiin. Pharmacological studies have shown that arctiin has significant anti-tumor, anti-virus, anti-oxidation and other physiological activities, which has attracted wide attention.

Because the content of arctiin is much higher than the content of arctiin, another active ingredient in arctiin, people also use chemical hydrolysis and biological transformation methods to convert arctiin into the required active substance. Therefore, in addition to its own drug utilization value, arctiin is also an important pharmaceutical raw material.

Chemical property

White crystalline powder, soluble in methanol, derived from burdock seed, forsythia, Corydoria.

use

Arctiin has antitumor and neuroprotective effects.

use

For content determination/identification/pharmacological experiments, etc. Pharmacological effect: It has anti-pancreatic cancer activity, and one of its mechanisms is to induce apoptosis. This product can cause blood vessel dilation, blood pressure drop; It causes convulsions in cold and warm blooded animals, respiratory failure in large doses, and skin redness and diarrhea in mice, and inhibits the isolated rabbit intestine and uterus. It can paralyze the motor nerves and bones, and can cause mild tail lifting reaction in mice.