What’s Wogonin?

Wogonin is an O-methylated flavonoid, a flavonoid compound found in Scutellaria baicalensis.

Wogonin Sources

Wogonin is a kind of flavonoids, which exists in different plants, and the highest content of wogonin is extracted from the root of Scutellaria baicalensis.

Scutellaria baicalensis, also called Huang Qin, Baikal skullcap, Chinese skullcap, is a plant of scutellaria (Labiaceae), whose dry roots are recorded in Chinese pharmacopeia, Scutellaria baicalensis has been widely used by China, and its neighbors for thousands of years. It grows mainly in temperate and tropical mountainous areas, including China, East Siberia of Russia, Mongolia, Korea, Japan, etc.

Constituents of Scutellaria baicalensis

Scutellaria baicalensis, on the other hand, has been widely used as a medicinal plant in China for thousands of years. Preparations made from its roots are used to treat diarrhea, dysentery, hypertension, bleeding, insomnia, inflammation, and respiratory infections.

It is reported that flavonoids such as wogonin and baicalein extracted from the root of Scutellaria baicalensis have a variety of pharmacological functions, including anti-cancer, liver protection, antibacterial, anti-viral, antioxidant, anti-convulsive, and neuroprotective effects.

Scutellaria baicalensis contains a variety of chemical components, such as various flavonoids, diterpenoids, polyphenols, amino acids, volatile oil, sterol, benzoic acid, and so on. The dry roots contain more than 110 kinds of flavonoids such as baicalin, baicalein, wogonoside, and wogonin, which are the main active ingredient of Scutellaria baicalensis. Standardized extract like 80%-90% HPLC Baicalin, 90%-98% HPLC Baicalein, 90%-95% HPLC Wogonoside, and 5%-98% HPLC Wogonin are all available from IdoBio .

Wogonin Specifications

• 5% wogonin powder HPLC
• 10% wogonin powder HPLC
• 95% wogonin powder HPLC
• 98% wogonin powder HPLC
• Shipment： Shipping by FedEx, by air, or by sea
• Package: Plastic bag inside, 1kg/bag, 25kg/drum

Wogonoside

Wogonoside, also named Oroxindin, Glychionide B, is the main flavonoid component of Scutellaria root, which has anti-inflammatory, anti-angiogenic, and anti-cancer and chemotherapy activities.

Wogonin vs Wogonoside

Wogonoside, a bioactive flavonoid, is a glycoside formed by wogonin and glucuronic acid. It is extracted from Oroxylum Indicum, Bacopa Monnieri, and Holmskioldia sanguinea. It is one of the active ingredients in the Japanese herbal supplement Sho-Saiko-to.

Wogonin and Baicalein, Baicalin

Baicalein is a cell-permeable flavonoid originally isolated from the root of Scutellaria baicalensis. It is an effective anti-inflammatory and anti-tumor agent with anti-thrombotic, anti-proliferation, and anti-mitosis effects.

Baicalin, a metabolite of baicalin, has anti-viral activity against the dengue virus.

Wogonin is also extracted and isolated from the root of Scutellaria baicalensis. It is of special value in various therapies as it has adjuvant benefits in the treatment of viral infection, anti-inflammatory, neuroprotection, anti-anxiety, and anti-convulsion.

wogonin and arthritis

Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory degeneration of articular cartilage and subchondral bone. Wogonin has been shown to have direct anti-inflammatory and antioxidant properties. In a mouse experiment, the study found that mice treated with wogonin were statistically more active than control mice and that the severity of OA in mice treated with wogonin was statistically significantly reduced.

Immunohistochemistry showed that the protein expression of transforming growth factor β1 (TGF-β1), high-temperature receptor A1 (HTRA1), matrix metalloproteinase 13 (MMP-13), and NF-κB were significantly decreased in mice treated with wogonin. Further enhancement of cartilage morphology was assessed in the form of reduced inflammation and OA biomarkers.

Wogonin Manufacturing Process

Wogonin was first isolated and identified from Scutellaria baicalensis in 1930. It can be found in different parts of Scutellaria baicalensis, such as root and whole grass, and in different plants, such as the leaves of Burm. F., stem drusus of affine hook. & Arn. Although the content of wogonin is the highest in Scutellaria baicalensis, the fact is that the yield is low and sometimes not enough to achieve industrial development.

Wogonin Benefits

Anti-tumor activity

Wogonin has anti-cancer activity against a variety of cancers, as shown in the table below.

In mouse experiments, wogonin showed its pro-apoptotic effect by inhibiting tumor growth activity in vitro and in vivo. The findings suggest that wogonin may have very high anti-cancer activity among the flavonoids tested and may interact positively with other phytochemicals even at low concentrations.

Anti-inflammation

According to clinical applications, Scutellaria baicalensis has a wide range of anti-inflammatory effects. For inflammatory cells, wogonin induces apoptosis. Inflammation is related to the expression of various proteins, and wogonin can inhibit the expression of these proteins to achieve an anti-inflammatory effect. PPAR-γ and NF-κB signaling pathways are also involved in the occurrence of inflammation, and wogonin improves cell viability by inhibiting NF-κB, MAPK, and phosphatidylinositol-3 kinase signaling pathways. It can be seen that wogonin exerts its anti-inflammatory effect mainly by inhibiting the release of inflammatory factors and the expression of inflammation-related proteins.

Anti-viral

T cell infiltration and cytotoxic T cell-mediated tissue damage are considered key factors in RSV disease. Wogonin can reduce T lymphocyte infiltration and pro-inflammatory factor gene expression and play an anti-viral effect. IAV can cause acute lung injury, which is manifested by abnormal lung index and lung tissue lesions. Scutellaria baicalensis extract can inhibit the spread of dengue virus, and wogonin is the main active ingredient in the extract.

Antioxidant

Scutellaria baicalensis has a strong antioxidant effect, which can indirectly exert a cytoprotective effect through antioxidant activity. The antioxidant activity of the polyphenol mixture from the four tissues of Scutellaria baicalensis was remarkable. Among Scutellaria baicalensis plants, roots have the highest antioxidant activity, followed by leaves, stems, and flowers. Studies have shown that wogonin can inhibit FeSO4-Cys-induced lipid peroxidation in liver homogenate, and has a strong cytoprotective effect on H2O2-induced oxidative damage to human umbilical vein endothelial cells.

Anti-neurodegeneration

Wogonin has neuroprotective effects on the rat brain after gamma irradiation. It restores cellular mRNA levels and expression of Nrf2, HO-1 and NF-κB. Wogonin and baicalein inhibit neuronal cell death. Multiple studies have shown that the polyhydroxyl structure of wogonin, a flavonoid, protects the brain from hypoxia induced by potassium cyanide or cerebral ischemia, and may inhibit the reciprocal regulation of neuroinflammation, oxidative stress, and neuronal injury Neuronal apoptosis. It may have potential preventive effects against neurodegenerative diseases.

Wogonin side effects

It can inhibit and kill tumor cells and has no toxic side effects on normal animal cells.

Wogonin dosage

Wogonin is currently mainly used in clinical trials for cancer, leukemia, etc. There are no dietary supplements with this ingredient on the market, and you need to consult your health doctor for dosage.