What is Cordycepin powder?

Cordycepine powder, cas no. 73-03-0, known as 3′-deoxyadenosine, was initially isolated from the fungus Cordyceps militaris.

Source of 3′-deoxyadenosine

• Fermentation extraction

The original strain did not produce a lot of Cordycepin powder. Still, by improving the culture procedures and conditions along with the proper culture medium, the yield of Cordycepin may be enhanced.

• Biosynthesis

Bioinformatics was used to identify potential synthetic gene clusters based on the genome analysis of Cordyceps militaris. The four proteins that the gene cluster encodes were examined for their gene functions. Adenosine 3′-OH was phosphorylated, dephosphorylated, then subjected to a redox process to create Cordycepin.

• Chemical synthesis

Adenosine was converted into cordycepin using a gentle and environmentally friendly process, yielding 99% HPLC purity.

Research History of Cordycepin

In 1951, A crystal known as Cordycepin was isolated and purified from the culture filtrate of Cordyceps militaris by German researchers Cunningham et al.

According to a 1989 report, the American SIGMA corporation recovered high-purity standards from Cordyceps militaris, and Cordycepin was isolated from the mycelia of the plant.

In 1997, The National Cancer Institute (NCI) included Cordycepin in 18 brand-new anti-cancer medications for research and development.

In 2000, Researchers from the NCI and Boston University School of Medicine professors collaborated to study and confirm Cordycepin’s beneficial effects on leukemia. Cordycepin has already entered the third phase of clinical studies.

In 2007, The clinical study of Cordycepin for the treatment of leukemia was approved by the US Food and Drug Administration (FDA).

In 2017, The production process of Cordycepin in Cordyceps militaris was thoroughly examined by Professor Wang Changshu of the Chinese Academy of s, and he discovered for the first time that Cordyceps militaris could generate the anti-cancer medication Penastatin.

Action mechanism of 3′-deoxyadenosine

According to some researchers, Cordycepin, a compound found in cordyceps fungi, prevents the development of tumors for three reasons:

(1) Cancer cells can be activated by incorporating the free alcohol group of Cordycepin into their DNA.

(2) it can stop nucleosides or nucleotides from being phosphorylated to form diphosphate and triphosphate derivatives, which prevents tumor cells from synthesizing nucleic acids.

(3) it can prevent xanthic acid from being aminated to guanylic acid.

Health Benefits

Regulate immunity

Interleukin-10 secretion can be increased by Cordycepin, which can also boost the expression of interleukin-10 mRNA and suppress interleukin-2 and peripheral blood monocyte growth.

The experiment demonstrated that interleukin-10 could protect the body from excessive immunological and pathological damage, indicating that Cordycepin can achieve immune regulatory negative feedback via improving IL-10 activity.

Antileukemic

Terminal deoxynucleotide positive leukemia cells (TdT+) are more inhibited by the adenosine deaminase inhibitor cordycepin than terminal deoxynucleotide negative leukemia cells (TdT-).

anti-tumor

The anti-tumor properties of Cordycepin

• Cordycepin can directly cause autophagy or cell death by acting on various cell signal transduction pathways.
• The indirect effect refers to the ability of Cordycepin’s anti-tumor active ingredient to improve immune cell performance and exert an anti-tumor influence by stimulating the growth and development of human immune cells.

By controlling the signal transduction pathway and preventing the tyrosine kinase enzyme’s ability to becoming more active, Cordycepin can prevent the growth of tumors.

Lewis lung cancer and the B16-BL6 mouse melanoma can both be slowed down by Cordycepin.

Through LXR-RXR heterogeneity activation, Cordycepin regulates the expression of miR-33b, which can target HMGA2, Twist1, and ZEB1, limit their presentation, and lessen melanoma migration and invasion.

Adenosine deaminase (ADA) is required for Cordycepin’s ability to prevent uveal melanoma cells from forming colonies and migrating.

Anti-aging

3-Deazaadenosine (3DA) improves cellular fitness and therapeutic cell efficacy in mice by reducing senescence.

It has been shown that S-adenosyl homocysteinase (AHCY) inhibitors, such as 3DA, can partially halt replicative and oncogene-induced senescence. In geriatric muscle stem cell cultures and regeneration studies utilizing human umbilical cord blood (UCB) cells, it confirmed the potential benefits of 3DA therapy, demonstrating that 3DA may boost the effectiveness of cellular therapies by preventing senescence.

Of course, Cordycepin also has additional effects, including antiviral, anticoagulant, hypolipidemic, and whitening properties.

Cordycepin Applications

Products from the Cordyceps series mainly concentrate on food consumed daily as a health supplement.

Additionally, there are other composite items available, including collagen, donkey hide gelatin, and additional premium raw ingredients. The absorption is more effective and scientific thanks to Cordycepin’s capacity for focused absorption.

idobio Cordycepin has yet to attain commercial production, the pharmaceutical industry still uses it the most. It needs to be clarified what the daily dosage is supposed to be.

Where to buy pure Cordycepin powder

idobio co,.ltd.has a professional R&D and production team to produce pure cordycepin powder with high purity.

The synthesis process of Cordycepin

Adenosine can be used as the starting material to make Cordycepin, which can then be made by reacting it with trimethyl orthoacetate to form the intermediate of 2′,3′-hydroxygenic acid esterification; adding acetyl bromide, hydrolyzing, and further preparing 2′,5′- o-diacetyl-3 ‘Bromo adenosine;2′,5’- o-diacetyl-3 ‘- deoxyadenosine is prepared by reduction; Cordycepin was synthesized by hydrolyzing and removing acetyl groups on the hydroxyl group of the sugar ring.