Physical and chemical properties

Sodium phosphocreatine appears as a white needle shaped crystalline powder and can be used as a pharmaceutical intermediate. It is soluble in water, insoluble in ethanol, and relatively stable in air.

application

Creatine phosphate is an important energy source in muscle contraction metabolism, serving as a chemical energy reserve for smooth and striated muscles and used for ATP synthesis. Phosphocreatine sodium is its medicinal form.

Sodium phosphocreatine can be used as a myocardial protectant, exerting various important physiological effects in the form of phosphocreatine in the body. 

It is widely used for myocardial protection in patients with cardiac ischemia or heart surgery, as well as for the treatment of cardiovascular diseases such as heart failure, myocardial infarction, and arrhythmia. 

It can improve the cardiac function and heart rate variability of patients with ischemic cardiomyopathy. 

It not only provides energy for myocardial cells during ischemia and hypoxia, but also protects the myocardial cell membrane from harmful substances such as oxygen free radicals. 

It has a protective effect on the postoperative myocardium of patients with heart failure and valve disease, which is beneficial for the recovery of cardiac function in patients with heart failure and valve disease after surgery. 

Using it for comprehensive treatment of myocardial damage after neonatal asphyxia can significantly improve myocardial enzymes and electrocardiogram, and has good efficacy and safety

Function characteristics

This product is a chemical energy reserve for myocardial and skeletal muscles, and is used for ATP synthesis to provide energy for the contraction process of myosin, playing an important role in energy metabolism during muscle contraction. Insufficient energy supply is an important factor in the formation and development of myocardial cell injury.

1. It has a significant protective effect on the contractile function of ischemic myocardium, allowing for sufficient recovery of contractility and rapid decrease in diastolic blood pressure.

2. Maintain the levels of adenosine triphosphate and creatine phosphate in cells to maintain myocardial energy reserves.

3. Reduce the loss of creatine kinase and alleviate damage to the cell membrane.

4. Has anti peroxidation properties.

5. Improve microcirculation of myocardium. Due to the presence of high-energy phosphate bonds in phosphocreatine molecules, the high-energy phosphate bonds are directly converted from ADP to ATP by phosphocreatine kinase, which can immediately provide energy to the body. And sodium fructose diphosphate, as an intermediate product of glycolysis, needs to exert its effect indirectly through anaerobic metabolism.