Appearance: light red solid
Purity: ≥ 98%
Specification: 3%  5% 10% 98%
Identification method: Mass, NMR
Analytical method: HPLC-DAD or/and HPLC-ELSD
Use: Used for content determination, identification, pharmacological experiment, etc.
Source of extraction: Gentiana manshurica Kitag Gentiana scabra Bunge, Gentiana triflora pall or Gentiana rigescens Franch Dry roots and rhizomes. Gentian has cholagogic, anti -, stomach - strengthening, hypotensive and other effects. Gentiana scabra mainly contains iridoid glycosides, and gentiopicroside is the main effective component.
Storage conditions: refrigerated at 4 ℃, sealed and protected from light.

Gentiana rigescens (G. rigescens) grows in the southwest region of China. The roots of this Chinese herb medicine have been used to treat inflammation, hepatitis, and functional dyspepsia [5]. Sheng Nong’s Herbal Classic, a classic book of traditional Chinese medicine on Materia Medica, described that G. rigescens has effects on cognition improvement and antiaging. In our previous study, 11 novel neuritogenic benzoate-type molecules (named gentisides A–K) were isolated from G. rigescens [6, 7]. The mixture of gentisides (n-GS) was confirmed to have alleviation effects on the impaired memory of scopolamine-induced mouse model by inhibiting acetylcholinesterase activities and antioxidative stress and regulating the insulin-like growth factor 1 receptor/extracellular signal-regulated kinase (IGF-1R/ERK) signal pathway [8]. These results possibly proved the cognition-improving effect of G. rigescens on the molecular basis, which was mentioned in Sheng Nong’s Herbal Classic.

In the present study, we investigated the antiaging molecular base of G. rigescens. Budding yeast Saccharomyces cerevisiae is a common aging model that has replicative and chronological lifespans. The K6001 strain, a yeast mutant strain derived from W303, has a characteristic that only mother cells can produce daughter cells and daughter cells do not continue to mitosis in glucose medium [2, 9]. The use of K6001 as a model to study replicative lifespan possesses many merits, such as low cost, short generation time, and easy operation. Therefore, the replicative lifespan assay of K6001 was utilised as a bioassay system to screen antiaging substances from food extracts and traditional Chinese medicines.

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