Introduction:

Ginsenoside Rb1 is a ginsenoside of the ginseng diol family, belonging to dammarane-type triterpenoid saponin compounds, 

which is mainly distributed in plants of the family of Pentaphyllaceae, such as ginseng, Panax ginseng, American ginseng, etc. 

It has a wide range of pharmacological activities, such as anti-aging, anti-cerebral ischemic injury, 

promoting regeneration of peripheral nerve cells, improving the function of learning and memory, antitumor, hypoglycemia, improvement of sexual function and anti-stress, etc.

 It is especially good at the central nervous system, the cardiovascular system, immune system, as well as anti-tumor, anti-hepatic thermal ischemia/reperfusion, anti-myocardial ischemia/reperfusion, anti-lung ischemia/reperfusion, etc. 

It has good medicinal value.

Physical and Chemical Properties

White amorphous powder or colorless crystals, slightly sweet and bitter taste, hygroscopic, generally unstable to acid, 

weak acid can be hydrolyzed, but after hydrolysis can not get the real original form of saponin elements.

 Soluble in water, methanol, ethanol, soluble in n-butanol, acetic acid, ethyl acetate, insoluble in ether, benzene. Optically active, mostly dextrose. 

Aqueous solution produces strong foam by shaking.

1.Anti-hepatic thermal ischemia-reperfusion injury

Ginsenoside Rb1 can prevent hepatic thermal ischemia-reperfusion injury.Rb1 can prevent hepatic ischemia-reperfusion injury.Rb1 has the potential to treat hepatic thermal ischemia-reperfusion via the ROS-NO-HIF pathway.

2. Anti-tumor effects

Ginsenoside Rb1 can effectively inhibit angiogenesis in vivo and in vitro. The mechanism may be through the estrogen receptor B modulation of pigment epithelium-derived factors to inhibit the formation of tubular structures, thus having anti-cancer and anti-angiogenic effects.

3. Effects on diabetes

The antidiabetic and insulin sensitizing effects of Rb1 may be achieved in part by modulating the development and function of adipocytes.3T3-L1 adipocytes treated with Rb1 showed a significant enhancement of basal glucose and insulin-mediated glucose uptake in the cells, which was accompanied by an up-regulation of the mRNA and protein levels of the glucose transporter 4.Rb1 also inhibited the proliferation of 3T3-L1 preadipocytes. In addition, Rb1 activates the insulin signaling pathway, promotes translocation of glucose transporter 1 and glucose transporter 4, and stimulates glucose transport in insulin-sensitive cells, thereby lowering blood glucose. Fibronectin may be a target protein that contributes to diabetic nephropathy, and ginsenoside Rb1 is able to prevent the high glucose-induced increase in fibronectin expression by inhibiting the amplification of the MAPK-Akt signaling cascade, which can attenuate diabetic complications.

4. Sexual function promotion

Ginsenoside Rb1 can improve sexual function. Ginsenoside Rb1 has a weak phytoestrogenic effect, which is mediated by binding to and activating estrogen receptors, and this effect is estrogen receptor-dependent.

5. Others

Protective effect against lipopolysaccharide-induced microcirculation disorders in rat mesentery, promotion of burn repair, inhibition of terephthalic acid (TPA)-induced cyclooxygenase initiating factor activity, anti-skin photodamage, and anti-ulcer effects.

Other Specification