(S)-2-(4-((((S)-2-AMino-5-Methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid,

 calciuM salt;L-5- Methyl leucovorin;Calcium (S)-2-(4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino;CALCIUML-5-METHYLTETRAHYDROFOLATE;(6S)-N-[4-(2-Amino-1,4,5,6,7,8,-hexahydro-5-methyl-4-oxo-6-pteridinylmethylamino)benzoyl]-L-glutaminsure, Calciumsalz (1:1);Calcium levomefolate;L-5-Methyltetrahydrofolate calcium;METHYL FOLATE CALCIUM SALT(METAFOLIN)(P)

Function

A lack of folic acid reduces the ability of cells to synthesize and repair DNA. Supplementing with folic acid may be a more beneficial approach. Increasing folic acid reduces homocysteine levels and supports normal cell proliferation, endothelial function, cardiovascular disease, nervous system function, and more. Supplementing 5-MTHF during pregnancy has been shown to reduce the risk of neural tube defects and their recurrence.

metabolic pathway

Ordinary folic acid must be converted into L-form methylfolate to participate in two major metabolic pathways: the methylation process and DNA synthesis. The only form of free folic acid that usually appears in human plasma and cells is 5-mthf. Lack of folic acid is usually due to insufficient absorption due to vitamin deficiency. The need for folic acid is increased during pregnancy and lactation, and during the growth of children. In the case of changes in absorption or metabolism or under the influence of drugs, eating folic acid-rich foods does not guarantee the dose provided and therefore needs to be given. Replenish.

Mechanism

Biochemical pathways for bioactive folate involve a series of enzymatic reactions and cofactors. Absorbed folate is reduced and methylated to 5-MTHF during intestinal mucosal cell metabolism. This conversion is limited and does not alter the presence of folate in the blood circulation. The heavy amino acid is subsequently converted to s-adenosylmethionine (SAMe), a methyl donor involved in numerous biochemical processes. It can also serve as a donor to participate in the synthesis of nucleotides, supporting biosynthetic DNA.

biological activity

Levomefolate calcium is a man-made form of folic acid that counteracts the effects of folic acid.

Indications and Usage for Levomefolate Calcium Algal Capsules

Levomefolate Calcium/ Algal Powder Capsules (15 mg-90.314 mg) are indicated for the distinct nutritional requirements of patients in need of advanced folate supplementation, specifically suboptimal L-methylfolate or maintenance-level needs, as determined by a licensed medical practitioner.

Levomefolate Calcium Algal Capsules Dosage and Administration

The usual adult dose is one capsule daily with or without food or as directed by a licensed medical practitioner.

FOLATE is essential for the production of certain coenzymes in many metabolic systems such as purine and pyrimidine synthesis. 

About 70% of food folate and cellular folate is comprised of L-methylfolate. 

It is the primary form of folate in circulation, and is also the form transported across membranes – particularly across the blood brain barrier – into peripheral tissues. 

In the cell, L-methylfolate is used in the remethylation of homocysteine to form methionine and tetrahydrofolate (THF). 

L-methylfolate is converted into functional, metabolically active coenzyme forms for use in the body, and supplies the active folate substrate, THF for use in transformylation and methylation biochemistry.1

Folates are best known for reducing the incidence of fetal neural tube defects (NTDs).2,3,4 NTDs are congenital malformations produced by failure of the neural tube to form and close properly during embryonic development.4,5 During the first four weeks of pregnancy – when many women do not even realize that they have conceived, adequate maternal folate intake is essential to reduce the risk of NTDs. 

Folate is also essential in the synthesis and maintenance of nucleoprotein in erythropoiesis. 

It also promotes white blood cell (WBC) and platelet production in folate-deficiency anemia. 

Folate is associated with methylation and transformylation biochemistry. Folate is involved in transformylation and methylation metabolism as well as, indirectly, succinylation metabolism (through the “methyl trap” hypothesis). Folate plays a central role in the formation of nucleic acid precursors, such as thymidylic acid and purine nucleotides, which are essential for nucleic acid synthesis and cell division. IOM/NAS (1998) noted that the evidence for a protective effect from folate supplements is much stronger than that for food folate.4 Other ingredients are added to folate as cofactors, coenzymes and co-metabolites; in studies by Czeizel and Dudas (1992) and Berry et al.

 (1999), factors other than folate intake may affect the magnitude of risk reduction or participate in a co-protective effect with folate.