Colorless crystals. Melting point of 53-54 ℃, boiling points of 257 ℃ (133kPa) and 158 ℃ (133Pa), relative density of 0.842380, refractive index of 1.452960. Easily soluble in alcohols, acetone, and benzene, soluble in ether, carbon disulfide, and chloroform, insoluble in water.

Pentadecanoic acid, as an important green chemical raw material, has excellent environmental performance, and its synthesis technology has attracted much attention. Pentadecanoic acid is also an important organic chemical intermediate, which contains functional groups such as carbonyl, methyl, and methoxy in its molecular structure. It can undergo various organic chemical reactions such as carbonylation, methylation, methoxylation, and methoxycarbonyl. Therefore, as a green raw material, it has a wide range of applications in organic synthesis. Due to its low toxicity and environmental friendliness, it can replace some toxic volatile organic compounds in applications such as coatings, pharmaceuticals, additives, and electronic chemicals. The structure of pentadecanoic acid molecules contains functional groups such as carbonyl, methyl, and methoxy. Due to the presence of three or more functional groups, and the fact that carbonyl and methyl do not produce substances that pollute the environment during chemical reactions with other substances, their chemical properties are relatively stable, making transportation safe and convenient.

synthetic method 

A suspension of benzoic acid (1.50mg) and FSM-16 (100mg) in dry hexane (5mL) was irradiated with a 400-W high-pressure mercury lamp at room temperature for 5 hours. Then filter FSM-16 and wash with ethyl acetate, and concentrate the filtrate under reduced pressure. After purification by TLC, pure benzophenone (35mg, 88%) was obtained. 9, yield 37%, 10, yield 30%. Finally, the compound pentadecanoic acid was obtained.

pharmacological action 

Pentadecanoic acid mainly promotes glucose uptake by adipocytes and skeletal muscle cells through the AMPK pathway. Pentadecanoic acid did not affect the fasting blood glucose level of type 2 diabetes mice, but it could improve hyperinsulinemia, protect islet cells, reduce serum cholesterol, reduce fat accumulation, and improve the inflammatory state of diabetes mice.

biological activity

Pentadecanoic acid is an endogenous saturated fatty acid. It is a plant metabolite, food ingredient, flea metabolite, human blood metabolite, and algal metabolite.

Target point

Human Endogenous Metabolite