CAS:518-28-5
Molecular formula: C22H22O8
Molecular weight: 414.41
Appearance): White to off white Solid
Storage conditions: Powder: 2-8 ℃, 2 years; In solvent (mother liquor): - 20 ℃, 1 month- 80℃, 6 months
Purity: HPLC ≥ 98%

Podophyllotoxin is the main cytotoxic ingredient of podophyllin, a resin used for many years for topical treatment of warts. The exact mechanism of action is unknown. Podophyllotoxin 0.5% solution or gel is similar in effectiveness to imiquimod but may have more adverse effects. Adverse effects include irritation of the adjacent skin, local erosion, ulceration and scarring.

Trichloroacetic acid, podophyllotoxin, and cryotherapy (with liquid nitrogen or a cryprobe) remain the most widely used treatments for external genital warts, but response rate is only 60–70%, and at least 20–30% of responders will have recurrence.
 

Podophyllotoxin possesses a large number of medical applications, as it is able to stop replication of both cellular and viral DNA by binding necessary enzymes. It can additionally destabilize microtubules and prevent cell division. Because of these interactions it is considered an antimitotic drug, although modern medicine instead use less orally toxic derivatives when such effect is wanted.

Podophyllotoxin cream is commonly prescribed as a potent topical antiviral.

 It is used for the treatment of HPV infections with external warts as well as molluscum contagisum infections.0.5% PPT cream is prescribed for twice daily applications for 3 days followed by 4 days with no application, this weekly cycle is repeated for 4 weeks.

 It can also be prescribed as a gel, as opposed to cream. PPT is also sold under the names condyline and warticon