Pregabalin belongs to non gamma aminobutyric acid (GABA) receptor agonists or antagonists, and is a novel calcium channel modulator that can block voltage dependent calcium channels and reduce neurotransmitter release. It is mainly used clinically for neuralgia related to diabetes peripheral neuropathy, post herpetic neuralgia and auxiliary treatment of adult partial epilepsy, generalized anxiety disorder, central neuralgia (including neuralgia associated with spinal cord injury, stroke and multiple sclerosis) and fibromyalgia.

Pregabalin is mainly used for the treatment of peripheral neuralgia and as an adjuvant therapy for localized partial epileptic seizures.

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pharmacological action 

Pregabalin has a good therapeutic effect on epilepsy. Studies on various animal models of epileptic seizures have shown that pregabalin can significantly prevent seizures, and its active dosage is 3-10 times lower than gabapentin. The study found that pregabalin can reduce the sensory and motor spinal cord reflex induced by toe pinching stimulation in rats, reduce the related behaviors of pain models of diabetes, peripheral nerve injury or chemical treatment of neurogenic animals, and inhibit or reduce the pain related behaviors caused by the stimulation given to the spine. Animal experiments have found that pregabalin may have advantages when used in combination with opioid drugs. Pregabalin provides a new option for clinical treatment of neuropathic pain.

Drug interactions

1. Not metabolized by the cytochrome P450 system, therefore, it rarely interacts with other drugs. Does not affect the pharmacokinetics of antiepileptic drugs (such as sodium valproate, phenytoin, lamotrigine, carbamazepine, phenobarbital, topiramate), oral contraceptives, oral hypoglycemic drugs, diuretics, insulin, etc.

When used together with oxycodone, the recognition function of this product decreases and the damage to motor function increases.

3. It has an additive effect with lorazepam and ethanol.