Spirostan-3-ol, (3β,5β,25S)-;Sarsasapogenin    baqia;

Spirostan-3-ol, (3b,5b,25S)-;PARIGENIN;SARSAGENIN;

Sarsagenin;Sarsasapogein;SARSASAPOGENIN; PARIGENIN;SASARASAPOGENIN 98.0% BY HPLC.

Sarsasapogenin (SAR, Parigenin) is a steroid saponin that can induce ROS production and activate the unfolded protein response (UPR) signaling pathway. SAR can effectively suppress NF- κ Activation of B and MAPK inhibits IRAK1, TAK1, and I in LPS stimulated macrophages κ B α Phosphorylation of.

Numerous studies have shown that Sarsasapogenin compounds in Anemarrhena asphodeloides have various effects such as treating senile dementia, neuroprotection, lowering blood sugar, enhancing immunity, and anti-aging. 

Moreover, due to the significant effects of Anemarrhena asphodeloides on senile dementia and neuroprotection, it has attracted increasing attention and attention from scholars both domestically and internationally.

In vitro research

The treatment with Sarsasapogenin can increase the number of S phase Hela cells, leading to the accumulation of G2/M phase cells. It can induce apoptosis in HeLa cells by inducing caspase dependent mitochondrial apoptosis pathways.

Sarsasapogenin induces activation of the endoplasmic reticulum stress response signaling pathway, inducing toxic effects on human cervical cancer cells through cell cycle arrest, ROS mediated mitochondrial pathway, and endoplasmic reticulum stress response pathway.

Sarsasapogenin can also induce early activation of UPR, activating CHOP - which may promote mitochondrial membrane permeability by dephosphorylation of Akt, thereby transmitting apoptotic signals from the endoplasmic reticulum to mitochondria.

Sarsasapogenin effectively inhibits NF- κ Activation of B and MAPK, inhibition of IRAK1, TAK1, and I in LPS stimulated macrophages κ B α Phosphorylation of. Sarsasapogenin also inhibits the binding of LPS to TLR4 receptors in macrophages, inhibiting M2 polarization into M1 macrophages.

Zhimu saponins and their aglycones have rich biological activities and pharmacological effects. A large number of patents related to their activity, pharmacological effects, and preparation processes have been applied for, and corresponding new drug research and development work is also underway. Especially, the preventive and therapeutic effects of saponins and their aglycones in elderly dementia, cardiovascular and cerebrovascular diseases, tumors, and osteoporosis are gradually being recognized and widely reported, and are receiving more and more attention. Therefore, the clinical application prospects of effective parts or monomeric components (such as saponins BII, AIII, etc.) are broad. However, their mechanisms of action and in vivo metabolism still need further systematic and in-depth elucidation, in order to accumulate sufficient research data for new drug development. The main pharmacological effects of Zhimu saponin and Zhimu saponin are as follows:

1. Prevention and treatment of senile dementia

2. Protective effect on cerebral ischemic injury

3. Anticoagulant effect

4. Antioxidant effect

5. Antitumor effects

6. Anti osteoporosis effect

7. Anti inflammatory effects

8. Hypotensive effect

9. Hypoglycemic effect