PURSENNIDE;SENNOSIDEB96.5+%;SennosideBstd.;9,9-Bianthracene-2,2-dicarboxylicacid,5,5-bis(.beta.-D-glucopyranosyloxy)-9,9,10,10-tetrahydro-4,4-dihydroxy-10,10-dioxo-,(9R,9S)-;(9S)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5R,Chemicalbook6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylicacid;SENNIDINEB(RG);SENNOSIDEB(P);SENNOSIDEB(SH).

Sennosides include sennosides A, B, C, D, E, F, G, etc. Among them, sennoside A and B, sennoside C and D, sennoside E and F are stereoisomers of each other, and sennoside G is the chiral isomer of sennoside A.

There are also sennoside I (aloe emodin dianthrone diglucoside) and sennoside II (10-10 'isomer of aloe emodin dianthrone diglucoside). Sennoside is found in cathartic senna, rhubarb and the cooling antidote Chebula.

Physical and chemical properties

Bright yellow prismatic crystals (dilute acetone), fine acicular crystals (water).

Melting point: 180 ~ 186℃(decomposition)[α]D:20-100°(c=0.2, 70% acetone), 2chemical book0-67°(c=0.4, 70% dioxane). Solubility: Soluble in sodium bicarbonate aqueous solution, slightly soluble in methanol, diethylene glycol monoethyl ether, acetone and dioxane hexasulfonate, insoluble in water, benzene, ether and chloroform.

Pharmacological action

Sennoside B can significantly reduce neuronal damage caused by glutamate NMDA increased LDH release, thereby protecting nerve cells.