Overview:
Tetrahydropiperine (THP) is a natural bioactive compound derived from Piper longum (long pepper). As a cyclohexyl analog of piperine, it exhibits enhanced bioavailability and diverse biological activities, making it valuable in pharmaceuticals, cosmetics, and research.

Key Properties & Benefits:

• Enhanced Bioavailability: Acts as a potent absorption enhancer for drugs and nutraceuticals.

• Cytochrome P450 Inhibition: Modulates drug metabolism (IC₅₀ ~23 μM for CYP1A1).

• TRPV1 Agonism: May support pain relief and anti-inflammatory effects (EC₅₀ ~6.3 μM).

• Skin Applications: Promotes melanogenesis and improves transdermal delivery of active ingredients.

• Safety: Used in cosmetics (up to 1% concentration) with mild irritancy potential.

Applications:

• Pharma: Drug adjuvant, metabolic modulator.

• Cosmetics: Skin-lightening, anti-aging, and penetration booster.

• Research: Tool compound for studying CYP450 and TRP channels.

Note: THP’s multifunctionality warrants further clinical validation for therapeutic uses.