Undecylenoyl phenylalanine, also known as acylamide, is a melanin-stimulating hormone (α-MSH) receptor antagonist. Generate signals to control the combination of α-MSH (melanocyte stimulating hormone) and melanin production factor, effectively inhibit the activity of tyrosinase, thereby inhibiting the formation of melanin. Mainly used in cosmetics as a whitening agent.

Details Table

Functions

1. It can effectively inhibit the formation of melanin caused by α-MSH, and can act on multiple stages of melanin formation to whiten or reduce the deposition of epidermal melanin, improve dark yellow, rough and other skin problems, even skin color, prevent , Delay and treat hyperpigmentation in the skin (eg post-inflammatory hyperpigmentation, pigmentation such as age spots, etc.).

2. It can be combined with nicotinamide, which can prevent melanin synthesis from the source (that is, inhibit melanin production signal and inhibit melanin production enzyme activity), while nicotinamide interferes with melanin synthesis pathway (that is, inhibiting the transport of melanin to the stratum corneum and accelerating melanin cutin Layer metabolism), cooperate with each other to exert the effect of whitening and lightening. It can be used to formulate stable and non-discoloring lotions, creams, transparent water preparations or gels, etc.

3. Undecylenoyl phenylalanine inhibits melanin, a melanin stimulator found in the skin. Melanotropin controls tyrosinase activity (tyrosinase is an essential enzyme for the production of melanin), melanin (eumalanin) synthesis, and melanosomes; therefore, by preventing the production of melanotropin, the pigmentation process is reduced or stopped.

Application direction

Undecylenoyl Phenylalanine is a compound containing amino acids and lipid residues used in cosmetic and personal care products, especially whitening formulations, to prevent melanin pigmentation in skin cells.

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Clinical studies:

A study was conducted to evaluate the efficacy and safety of a formulation containing 2% Undecylenoyl Phenylalanine in the topical treatment of solar pigmentation. A total of 36 patients with solar naevus of the hand were randomly assigned to receive active formulation on one side and vehicle only on the other side twice daily for 12 weeks. 2% is a novel depigmenting agent that may act as an alpha-melanocyte stimulating hormone antagonist, thereby inhibiting melanin production. It achieves significant reduction of lesions with minimal side effects. Most patients were satisfied with the improvement.